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RECRUITINGNCT04099082

Signature of the Host Response to a Respiratory Viral Infection, in the Prediction of Bronchiolitis Obliterans

Bronchiolitis obliterans (BO) is the well-known manifestation of the chronic pulmonary graft-versus-host disease(GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The pathophysiol...

Lead sponsor: Assistance Publique - Hôpitaux de Paris•1 locations•View source on ClinicalTrials.gov

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Contacts

David Michonneau, MD PhD

CONTACT

1 42 49 49 49 david.michonneau@aphp.fr

Jérôme Lambert, MD PhD

CONTACT

142499742 jerome.lambert@u-paris.fr

Sponsors

Lead Sponsor

Assistance Publique - Hôpitaux de Paris

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Adults having received a hematopoietic stem cell transplantation for less than two years
•Availability of respiratory function tests prior to infection
•Presence of PIV respiratory infection documented by identification of the virus by PCR in the upper and/or lower respiratory tract
•Symptoms of respiratory infection ≤ 5 days
•Signed informed consent

Exclusion Criteria

•Presence of a respiratory virus infection other than PIV
•Viral respiratory co-infections
•Bacterial or fungal respiratory infections
•Treatment with ribavirin, oseltamivir or any other antiviral with activity against respiratory viruses
•Patient not affiliated or beneficiary of a social security system
•Patient deprived of liberty or protected
•Pregnant or breastfeeding woman

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: July 17, 2024Terms

Trial snapshot

StatusRECRUITING

Phase—

Enrollment14

Start dateMar 2021

Last updatedJul 17, 2024

Condition

Allogeneic Hematopoietic Stem Cell Recipients Acute Respiratory Infection Parainfluenza Virus (PIV)

Locations shown

Saint Louis

Paris, Île-de-France Region

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 17, 2024Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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