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Clareo Health | Steroids and Cross-linking for Ulcer Treatment

Steroids and Cross-linking for Ulcer Treatment

NCT04097730·3 sites·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Lead

Thomas M. Lietman

With

Aravind Eye Care System
National Eye Institute (NEI)
University of Miami
Stanford University

Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

Corneal ulcer that is smear positive and/or culture positive (within 24 hours) for typical bacteria (i.e. non-Nocardia or Mycobacteria)
Moderate to severe vision loss, defined as Snellen visual acuity of 20/40 (6/12) or worse
Corneal thickness ≥350 µm, as measured on AS-OCT
Age over 18 years
Basic understanding of the study as determined by the physician
Commitment to return for follow up visits

You may not be if

Evidence of concomitant infection on exam, gram stain, or confocal microscopy (i.e. herpes, both bacteria and acanthameoba on gram stain)
Impending or frank perforation at recruitment
Involvement of sclera at presentation
Non-infectious or autoimmune keratitis
History of corneal transplantation or recent intraocular surgery
Pinhole visual acuity worse than 20/200 in the unaffected eye
Participants who are decisionally and/or cognitively impaired

The record

StatusCompleted

PhasePhase 3

Taking part280

StartedSep 2020

UpdatedFeb 3, 2025

Conditions

Keratitis Bacterial

Where3

Francis I. Proctor Foundaiton
San Francisco, California, United States
University of Miami
Miami, Florida, United States
Aravind Eye Care System
Madurai, Tamil Nadu, India