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Integrative Medicine for Pain in Patients With Advanced Cancer Trial (IMPACT)

NCT04095234•Memorial Sloan Kettering Cancer Center

Summary

The purpose of this study is to compare the long-term effectiveness of acupuncture versus massage in people living with advanced cancer. The study will test how the two approaches compare in helping people with pain and its related symptoms and improving quality of life.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age ≥ 18 years or older
•Having a diagnosis of the following: stage III or IV lung cancer; any stage pancreatic cancer; unresectable cholangiocarcinoma; unresectable liver cancer; unresectable ampullary or peri-ampullary cancer or other stage IV gastrointestinal cancer; stage III or IV ovarian or fallopian tube cancers or other stage IV gynecologic cancer; stage IV breast cancer; stage III testicular cancer; stage IV genitourinary cancer; stage III or IV sarcoma; stage IV melanoma; stage III or IV head/neck cancer; stage IV endocrine cancer; or hematological malignancies (lymphoma, myeloma, and leukemia)
•Be ambulatory (Karnofsky functional score of ≥ 60)
•Having musculoskeletal pain, defined as regional (joints, extremities, back, neck) or more generalized (fibromyalgia or chronic widespread pain); Patients with a neuropathic component to their pain that involves the extremities or back will be eligible.
•Having musculoskeletal pain for at least 1 month
•Having had pain for at least 15 days in the preceding 30 days
•Having a pain rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week
•Having an expected prognosis of greater than six months as judged by the treating oncologist or study physician

Exclusion Criteria

•Having a platelet count \<15,000
•Cognitive impairment precluding response to study assessments
•Unwilling to accept random assignment
•Unwilling to commit to the 26-week study time period
•Have non-musculoskeletal pain syndromes (headache, facial pain, chest pain, visceral abdominal pain) if these are the sole source of pain but can be present as co-morbid conditions as long as a patient has a primary musculoskeletal pain condition defined as above.

Locations (8)

Baptist Alliance MCI

Miami, Florida, United States

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey, United States

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen (All Protocol Activities)

Montvale, New Jersey, United States

Memorial Sloan Kettering Commack (All Protocol Activities)

Commack, New York, United States

Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York, United States

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, United States

Memorial Sloan Kettering Nassau (All Protocol Activities)

Uniondale, New York, United States

Key Dates

Start Date

September 17, 2019

Primary Completion Date

September 30, 2022

Completion Date

September 1, 2026

Last Updated

October 10, 2025

Enrollment

300

ACTUAL participants

Conditions

Cancer Pain

Interventions

Acupuncture

PROCEDURE

Massage

PROCEDURE

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 10, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Integrative Medicine for Pain in Patients With Advanced Cancer Trial (IMPACT)

Inclusion Criteria

Exclusion Criteria

Phase I Study of sss40 Injection for Moderate-to-Severe Bone Metastatic Cancer Pain

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