The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

Inclusion Criteria

• •1. male or female 30 years or older,
• •2. Infrainguinal PAD,
• •3. critical limb ischemia, defined as arterial insufficiency with gangrene, nonhealing ischemic ulcer, or rest pain consistent,
• •4. candidate for both endovascular and open infra-inguinal revascularization as judged by the vascular surgeons,
• •5. absence of musculoskeletal (most commonly arthritis related) or neurologic (most commonly back pain and sciatica related) symptoms,
• •6. willingness to comply with protocol, attend follow-up appointments, complete all study assessments, and provide written informed consent.