Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation

Exclusion Criteria

• •a lifetime psychiatric history of bipolar disorder, schizophrenia, psychotic disorders, or organic mental disorder including substance abuse and dependence (based on DSM-IV criteria)
• •Participants with a lifetime medical history of major systemic illness and clinically significantly abnormal screening examination that might affect safety, study participation, or confound interpretation of study results.
• •Participants with a lifetime medical history of neurological disorder records (e.g., stroke, seizure, traumatic brain injury, post brain surgery), brain implants (neurostimulators), cardiac pacemakers
• •Women with breastfeeding or pregnancy
• •Participants with a current strong suicidal risk (i.e., a score of 4 on item 3 of the HDRS-17)