Metabolomic and Inflammatory Effects of Oral Aspirin (ASA) in Subjects at Risk for Melanoma

Primary Objectives I. Open label trial in 60 patients to assess the capacity of either of one daily dose (81, 325 mg) of sub-chronic ASA administration to increase the plasma and nevus ASA metabolites such as: salicylate, salicylurate, gentisic acid, and salicyl acyl glucuronide. II. Open label trial in 60 patients to assess the capacity of sub-chronic daily ASA (81, 325 mg) administration to reduce levels of prostaglandin E2 (PGE2) in plasma and nevi. Secondary Objectives I. Determine whether ASA increases AMP-activated protein kinase (AMPK) activation in nevi. II. Determine whether ASA affects whole blood leukocytes or leukocyte subsets in plasma. III. Determine whether ASA affects inflammatory cytokines in plasma.