Dual Vaccine Trial in Myeloproliferative Neoplasms

Exclusion Criteria

• •1. Other malignancies in the medical history excluding basal cell carcinoma. Patients cured for another malignant disease with no sign of relapse five years after ended treatment is allowed to enter the protocol.
• •2. Significant medical condition per investigators judgement e.g. severe Asthma/COPD, poorly regulated heart condition, insulin dependent diabetes mellitus.
• •3. Acute or chronic viral or bacterial infection e.g. HIV, hepatitis or tuberculosis
• •4. Serious known allergies or earlier anaphylactic reactions.
• •5. Known sensibility to Montanide ISA-51
• •6. Any active autoimmune diseases e.g. autoimmune neutropenia, thrombocytopenia or hemolytic anemia, systemic lupus erythematosus, scleroderma, myasthenia gravis, autoimmune glomerulonephritis, autoimmune adrenal deficiency, autoimmune thyroiditis etc.
• •7. Pregnant and breastfeeding women.
• •8. Fertile women not using secure contraception with a failure rate less than \< 1%
• •9. Patients taking immune suppressive medications incl. systemic corticosteroids and methotrexate at the time of enrollment
• •10. Psychiatric disorders that per investigator judgment could influence compliance.
• •11. Treatment with other experimental drugs
• •12. Treatment with other anti-cancer drugs - except IFN-a, hydroxyurea or anagrelide.
• •13. Treatment with ruxolitinib.
• •14. Treatment with chemotherapy or immune therapy (excluding IFN-a, hydroxyurea or anagrelide) within the last 28 days.