A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Activity of Tiragolumab in Participants With Relapsed or Refractory Multiple Myeloma or With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
Life expectancy of \>/= 12 weeks
Arm A only: Must have R/R MM for which no established therapy for MM is appropriate and available or be intolerant to those established therapies
Arms C and E only: Participants with R/R MM who have received at least 3 prior lines of therapy.
Measurable disease defined by laboratory test results.
Participants with histologically confirmed B-cell NHL who have relapsed or failed to respond to at least two prior systemic treatment regimens and for which no suitable therapy of curative intent or higher priority exists.
Must have at least one bi-dimensionally measurable lesion.

Any anti-cancer therapy, whether investigational or approved, including chemotherapy, monoclonal antibody, radioimmunoconjugate, antibody-drug conjugate, hormonal therapy, and/or radiotherapy, within 4 weeks or 5 half-lives of the drug, whichever is shorter, prior to initiation of study treatment
Prior treatment with any anti-TIGIT agent
Prior treatment with chimeric antigen receptor-T (CAR-T) therapy within 12 weeks before first study drug administration
Autologous Stem-Cell Transplantation (ASCT) within 100 days prior to first study drug administration
Active or history of autoimmune disease or immune deficiency
Known active bacterial, viral (including SARS-CoV-2), fungal, mycobacterial, parasitic, or other infection at study enrollment, or any major episode of infection within 4 weeks prior to first study drug administration
Primary or secondary plasma cell leukemia
Current or history of CNS involvement by MM
Uncontrolled hypercalcemia or symptomatic hypercalcemia requiring continued use of bisphosphonate therapy or denosumab
Current or history of CNS lymphoma
Current eligibility for ASCT