* On a stable medication regimen for at least two weeks prior to testing
* A clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
* Able to complete a PET-MR scan without the use of sedation
You may not be if
Active substance use within three months of testing
IQ \< 70
Major medical neurological illness or significant head trauma
Pregnancy or breastfeeding
Contraindication to MR scanning, including magnetic-resonance incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ
Weight \> 350 lbs or a large body habitus that MR scanner cannot accommodate
History of or current claustrophobia
Inability to comply with basic study requirements such as following directions and punctuality
For HC participants:
* Presence of a first degree relative with a psychotic disorder
* Lifetime diagnosis of major psychiatric illness
For SZ participants:
* Unstable psychiatric symptoms at the time of testing, e.g. acute suicidality, prominent psychosis, or behavioral dyscontrol
Clareo Health | Imaging Synapses With [11C] UCB-J in the Human Brain
