Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

Exclusion Criteria

• •1. Inability or unwillingness to provide written informed consent
• •2. Moderate/severe cognitive impairment
• •3. Current or lifetime diagnosis of psychosis-related disorder, bipolar I or II disorder, substance-induced mood disorder, or any mood disorder due to a general medical condition
• •4. History of moderate or severe traumatic brain injury
• •5. History of comorbid substance disorder within 1 month of screening
• •6. Prior use of ketamine as an antidepressant
• •7. Clinically unstable medical illness
• •8. For women: pregnancy (confirmed by baseline lab test), the initiation of female hormonal treatments within 3 months of screening, or inability or unwillingness to use a medically accepted contraceptive method for the duration of the study
• •9. Imminent risk of suicidal/homicidal ideation and/or behavior
• •10. Inability to undergo MRI (i.e. claustrophobia, ferromagnetic implants, etc.)
• •1. Inability or unwillingness to provide written informed consent
• •2. Moderate/severe cognitive impairment
• •3. History of any major medical or psychiatric disorders
• •4. Current or lifetime diagnosis of psychosis-related disorder, bipolar I or II disorder, substance-induced mood disorder, or any mood disorder due to a general medical condition
• •5. History of moderate or severe traumatic brain injury
• •6. History of comorbid substance disorder within 1 month of screening
• •7. Prior use of ketamine as an antidepressant
• •8. Clinically unstable medical illness
• •9. For women: pregnancy (confirmed by baseline lab test), the initiation of female hormonal treatments within 3 months of screening, or inability or unwillingness to use a medically accepted contraceptive method for the duration of the study
• •10. Imminent risk of suicidal/homicidal ideation and/or behavior
• •11. Inability to undergo MRI (i.e. claustrophobia, ferromagnetic implants, etc.)
• •1. Inability or unwillingness to provide written informed consent
• •2. Moderate/severe cognitive impairment
• •3. Meet DSM-5 criteria for PTSD or subthreshold PTSD
• •4. Current or lifetime diagnosis of psychosis-related disorder, bipolar I or II disorder, substance-induced mood disorder, or any mood disorder due to a general medical condition
• •5. History of moderate or severe traumatic brain injury
• •6. History of comorbid substance disorder within 1 month of screening
• •7. Prior use of ketamine as an antidepressant
• •8. Clinically unstable medical illness
• •9. For women: pregnancy (confirmed by baseline lab test), the initiation of female hormonal treatments within 3 months of screening, or inability or unwillingness to use a medically accepted contraceptive method for the duration of the study
• •10. Imminent risk of suicidal/homicidal ideation and/or behavior
• •11. Inability to undergo MRI (i.e. claustrophobia, ferromagnetic implants, etc.)
• •1. Inability or unwillingness to provide written informed consent
• •2. Moderate/severe cognitive impairment
• •3. Meet DSM-5 criteria for a diagnosis of MDD, single or recurrent, moderate to severe
• •4. Current or lifetime diagnosis of psychosis-related disorder, bipolar I or II disorder, substance-induced mood disorder, or any mood disorder due to a general medical condition
• •5. History of moderate or severe traumatic brain injury
• •6. History of comorbid substance disorder within 1 month of screening
• •7. Prior use of ketamine as an antidepressant
• •8. Clinically unstable medical illness
• •9. For women: pregnancy (confirmed by baseline lab test), the initiation of female hormonal treatments within 3 months of screening, or inability or unwillingness to use a medically accepted contraceptive method for the duration of the study
• •10. Imminent risk of suicidal/homicidal ideation and/or behavior
• •11. Inability to undergo MRI (i.e. claustrophobia, ferromagnetic implants, etc.)