The study team will recruit individuals based on genetic risk score for type 2 diabetes from the biobank populations who have agreed to be recontacted for future research. Each participant will undergo a frequently sampled four-hour oral glucose tolerance test and whole body DXA scan (dual-energy X-ray absorptiometry) in addition to baseline laboratory and history assessment.
Age
10–70
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Age 10-70 years
Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
You may not be if
prior diagnosis of type 1, type 2, or secondary diabetes
use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
acute illness that may impact insulin and glucose dynamics
pregnancy
hypothalamic obesity or related genetic disorder of metabolism
recent systemic chemotherapy use
gastrointestinal impairment or surgery that may impact absorption
anemia
major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
