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Influence of Preprandial Metformin Administration on Carbohydrate Absorption: Pilot Randomized Controlled Study
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption. It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake. To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.
Age
18 - 60 years
Sex
FEMALE
Healthy Volunteers
No
Start Date
December 1, 2022
Primary Completion Date
December 1, 2024
Completion Date
December 1, 2024
Last Updated
August 19, 2022
24
ESTIMATED participants
Oral glucose tolerance test (OGTT) with or without metformin
OTHER
Lead Sponsor
University Hospital, Lille
NCT04564391
NCT03851627
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