Lead Sponsor

Hospices Civils de Lyon

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Control population:
•Male or female
•18 years old and over
•Be part of cohorts STRAMBO, OFELY or MODAM
•Patients with OI:
•Male or female ≥18 years old
•Have COL1A1 or COL1A2 mutation
•Have a diagnosis of type 1 or 3 from Silence classification made by a rheumatologist expert in bone pathologies

•Refusal to participate in the study
•Have received glucocorticoid treatment for more than 3 months
•Have received anti-osteoporotic treatment for less than 1 year ago
•Have Chronic inflammatory rheumatism
•Have an uncontrolled hypo/hyper thyroidism ou hypo/hyper parathyroidism
•Have cancer or bone metastases (current or in the past two years)
•Have benign bone tumors or Paget's disease
•Have malabsorptive disease (Celiac disease, Whipple's disease, intestinal bypass, short bowel syndrome) and inflammatory bowel disease
•Pregnant or lactating women
•Have psychiatric disorders seriously hindering understanding
•Have difficulties in oral understanding of French language
•Not a beneficiary of french social security
•Patients protected by law