Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances

Exclusion Criteria

• •1. Patients with untreated cataracts grades 1-4
• •2. Patients who wear contact lenses
• •3. Less than 5 weeks post-refractive surgery (LASIK or PRK)
• •4. Less than 5 weeks post intraocular lens insertion
• •5. Low blood pressure (systolic \<120 mm Hg or diastolic \<80 mm Hg)
• •6. A history of heart rate abnormalities
• •7. Administration of any investigational drug within 30 days of study initiation
• •8. Use of any eye drops with a pharmacologic effect on the pupil within 7 days of Visit 1
• •9. Use of any systemic alpha adrenergic antagonists (Appendix 1)
• •10. Known local or systemic hypersensitivity to adrenergic antagonists
• •11. For women of childbearing potential: currently pregnant or lactating, or unwilling to use birth control during the study