This is a prospective cohort study that examines the impact of myopenia on chemotherapy toxicity in overall survival (OS) in older adults with newly diagnosed metastatic colorectal cancer (CRC) receiving 5-Fluouracil (5FU)systemic chemotherapy. The study also explores the mediating influence of genetic variation in the association between myopenia and chemotherapy toxicity.
Age
60–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Newly diagnosed metastatic CRC or newly recognized metastatic recurrence of CRC \>= to 3 months (12 weeks) from completion of treatment of non-metastatic CRC.
Planning to or recently started to undergo undergo immunotherapy and/or 5-FU based chemotherapy as a first line of treatment. 5-FU chemotherapy can be 5-FU alone or in combination with oxaliplatin and/or irinotecan +/- immunotherapy. Capecitabine is also acceptable.
Estimated life expectancy \>= 6 months.
Patients must be able to comprehend English or Spanish (for questionnaire completion).
Ability to understand and the willingness to sign a written informed consent document.
Patient eligibility is not dependent on BMI or weight. Patients with a significant (+- \> 10%) body weight change in the previous 12 months are eligible for this study.
You may not be if
Patients enrolled on hospice.
Prior systemic chemotherapy for metastatic colorectal cancer (ok if adjuvant chemotherapy completed \>= 3 months (12 weeks) prior to this disease disease recurrence and treatment).
Patients may not be receiving any other investigational agents.
No untreated brain metastases. Patients with treated brain metastases are eligible.
Patients on or planned to undergo radiation therapy in near future.
Clareo Health | Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
