A Study to Assess the Effect of a 3-month Folate Supplementation on Systemic Homocysteine Plasma Concentration and Ocular Blood Flow in Patients With Diabetes

Exclusion Criteria

• •Participation in a clinical trial in the 3 weeks preceding the screening visit
• •Symptoms of a clinically relevant illness in the 3 weeks before the first study day
• •Presence or history of a severe medical condition relevant to the study, except diabetes, as judged by the clinical investigator
• •Intake of dietary supplements containing folate within the three months before the screening visit
• •Untreated or uncontrolled arterial hypertension (defined as either systolic blood pressure \>150 mmHg or diastolic blood pressure \>95 mmHg)
• •Blood donation during the previous three weeks
• •Moderate to severe non-proliferative or proliferative diabetic retinopathy
• •Previous laser photocoagulation treatment
• •History or family history of epilepsy
• •Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator
• •Best corrected visual acuity \< 0.8 Snellen
• •Ametropy \> 6 Dpt
• •Pregnancy, planned pregnancy or lactating