Male patient ≥ 50 years old

Histologically confirmed adenocarcinoma of the prostate

Gleason ≤ 7 (3 + 4) ; Grade group ≤ 2 according to Epstein

Clinically \<T3, N0, M0

PSA \< 15 ng/mL

Prostate volume \<100g

Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

Life expectancy higher than 12 months in the judgement of the investigator

Radiological TNM (prostate MRI) T ≤ 2 (absence of extra-capsular extension, absence of seminal vesicle invasion), N = 0, M = 0

First line of treatment or relapse after initial radiotherapy

Willing to give signed, informed consent freely

Able to adhere to the follow-up schedule and other protocol requirements.

MRI- Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer