A Study of SHR-1501 Combined With SHR-1316 in Patients With Advanced Tumors

Exclusion Criteria

• •1. Patients with cancerous meningitis (ie meningeal metastasis);
• •2. Patients with active central nervous system (CNS) metastasis.
• •3. Spinal cord compression that cannot be radically treated with surgery and/or radiotherapy cannot be enrolled.
• •4. Patients with double cancer or more serious cancer;
• •5. Patients with a history of autoimmune diseases;
• •6. Significant clinical significance in the history of cardiovascular disease;
• •7. Arterial/venous thrombosis events such as cerebrovascular accidents deep vein thrombosis and pulmonary embolism within 6 months prior to first administration;
• •8. Have a history of immunodeficiency including HIV infection;
• •9. Active hepatitis B or hepatitis C patients;
• •10. Any disease or symptom that is not appropriate for inclusion in this study determined by the investigator.;
• •11. Patients have undergone major surgery within 28 days prior to the first dose (except for diagnostics);
• •12. Those who used a live attenuated vaccine within 4 weeks prior to the first dose or expect a live attenuated vaccine during the study period;
• •13. Those who received other clinical trials within 4 weeks prior to the first study;
• •14. Those who received systemic immunosuppressive therapy within 2 weeks prior to the first study dose;
• •15. Patients who have previously received allogeneic bone marrow transplantation or solid organ transplantation;
• •16. A history of severe allergic reactions to other monoclonal antibody/fusion protein drugs;
• •17. Mental illness, alcohol abuse, drug abuse or substance abuse;
• •18. Any disease or condition that causes reasonable suspicion to prohibit the use of the study drug or affect the interpretation of the study results or the patient is at high risk of treatment complications (any other disease, metabolic disorder, physical examination results or laboratory tests abnormalities);
• •19. Pregnant or lactating women or women planning to become pregnant during the study.