Interest of the Study of Electroencephalogram and Peripheral Vegetative Markers for the Evaluation of Nociception Under General Anesthesia.

Exclusion Criteria

• •Subject to a measure of legal protection (tutelage, guardianship)
• •Admitted for emergency surgery
• •With known allergy to any of the anesthetic agents used in the study
• •Having been asleep under general anesthesia in the 7 days preceding the intervention
• •A pacemaker or heart transplant patient
• •With a history of Parkinson's disease, insulin-dependent or non-insulin-dependent diabetes at a dysautonomic stage or chronic alcoholism at a dysautonomia stage
• •With psychiatric history or severe depression
• •Presenting a peripheral or central neurological pathology that may modify the physiological responses to nociceptive stimulation
• •With abnormal heart rhythm (atrial fibrillation or frequent extrasystoles)
• •Treated for arterial hypertension with angiotensin type 2 receptor antagonists
• •Treated with anti-arrhythmic, α- or β-blocking, which would make the interpretation of the results more difficult
• •With chronic pain
• •Treated with morphine or long-term neuroleptic
• •Consuming cannabis or another narcotic
• •Presenting bilateral ocular pathology that may interfere with pupillary dilatation
• •Or refusing to participate in the study.