Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel

Exclusion Criteria

• •1. BCVA at baseline \<20/40.
• •2. Wearing contact lens only in one eye.
• •3. Wearers of the following contact lenses: Extended wear, prosthetic, scleral, and intracorneal gas permeable.
• •4. Pregnant women or women of childbearing potential who are not using contraception.
• •5. Diagnosis of the following autoimmune diseases: Addison's disease, Grave's disease, Hashimoto's thyroiditis, lupus, and Sjogren's syndrome.
• •6. Comorbidity with other severe or chronic eye conditions that in the judgment of the investigator will interfere with study assessments, such dystrophies, infections, etc.
• •7. Has a condition or be in a situation that, the opinion of the investigator, that may interfere significantly with the subject's participation in the study. No active ocular condition or disease.
• •8. Has a known adverse reaction and/or sensitivity to either study drug or its components.
• •9. Unwilling to remove contact lens overnight.
• •10. Unwilling to attempt to wear contact lens seven (7) days a week during the study period.
• •11. Plan to change brand of contact lens during study period.
• •12. Unwilling to wear contact lens for at least 10 hours if comfort permits, or until discomfort requires removal of contact lens prior to 10 hours.
• •13. Unwilling to discontinue swimming with immersed head for the duration of the study.
• •14. Unwilling to withhold the use of artificial tears, gels, or wetting agents during periods when contact lens is worn during the study period.
• •15. Cannot withhold the following medications during the study period:
• •antihistamines, some diuretics, antidepressants, antipsychotics, Restasis, Xiidra, Accutane, glaucoma medications, other anti-cholinergics; as well as gabapentin.
• •16. Currently enrolled in an investigational drug or device study or have used an investigational drug or device within 30 days prior to Visit 1.