Rodrigo A Athanazio, MD, PhD

CONTACT

Lead Sponsor

University of Sao Paulo General Hospital

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Age \> 18 years;
•Diagnosis of bronchiectasis by chest tomography;
•FEV1 \<60% of predicted;
•History of chronic bronchitis (chronic cough and sputum for at least 3 months in the last 2 years);
•2 or more infectious exacerbations in the last year (defined as worsening of cough and / or dyspnoea and / or decreased general condition, increased quantity and purulence of sputum that required systemic antibiotic use (oral or intravenous).

•Hemoptysis in the last 6 months (significance at the discretion of the investigator);
•Current or prior smoking if \> 10 pack-years;
•FEV1 \< 30% of predicted;
•Known allergy to roflumilast;
•Pulmonary exacerbation present or occurring in the last 4 weeks;
•Child B or C cirrhosis;
•Active cancer (except basal cell carcinoma);
•Severe heart failure;
•Depression associated with suicidal ideation;
•Pregnancy.