Reproductive Axis Maturation in the Early Post-Menarchal Years

Exclusion Criteria

• •Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).
• •Planning to move more than 60 miles from the CRU within the next 2 to 3 years
• •Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.
• •First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder
• •Excessive exercise (defined as running \>20 miles per week or its equivalent)
• •Pregnancy
• •Part 2 - Post-menarche cycle tracking:
• •Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).
• •Planning to move more than 60 miles from the CRU within the next 2 to 3 years
• •Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.
• •First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder
• •Excessive exercise (defined as running \>20 miles per week or its equivalent)
• •Anemia (defined as hemoglobin \<12.0 g/dl)
• •--Participants with hemoglobin between 11.5 g/dl and 12.0 g/dl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.
• •Pregnancy
• •Part 3 - Intensive monitoring of ovarian follicle growth
• •Taking or planning to take medications that affect reproductive hormones in the next 1-2 years (e.g. birth control pills, biotin supplements).
• •Planning to move more than 60 miles from the CRU within the next year
• •Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.
• •First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder
• •Excessive exercise (defined as running \>20 miles per week or its equivalent)
• •Anemia (defined as hemoglobin \<12.0 g/dl)
• •--Participants with hemoglobin between 11.5 g/dl and 12.0 g/dl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.
• •Pregnancy
• •Part 4 - Late Post-menarche cycle tracking:
• •Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).
• •Planning to move more than 60 miles from the CRU within the next 6 months
• •Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.
• •Anemia (defined as hemoglobin \<12.0 g/dl)
• •--Participants with hemoglobin between 11.5 g/dl and 12.0 g/dl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.
• •Pregnancy
• •Adolescent girls, at-risk daughters, or sisters of women with PCOS
• •Women with known PCOS (activities for 8 weeks only)
• •Cannot be taking any medications that affect reproductive or metabolic hormones (e.g. birth control pill, biotin supplements, spironolactone, metformin).
• •Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.
• •Pregnancy
• •Healthy control women (Activities x 2 menstrual cycles)
• •Cannot be taking any medications that affect reproductive or metabolic hormones (e.g. birth control pill, biotin supplements, spironolactone, metformin).
• •Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.
• •PCOS diagnosis or first-degree relative with disorder
• •Pregnancy
• •Mothers of pediatric participants (Activities for 8 weeks / 2 menstrual cycles)
• •Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.
• •Pregnancy