Low-dose Interleukin-2 in Women With Unexplained Miscarriages

Exclusion Criteria

• •Uterine or pelvic abnormality: uterine malformation, intracavitary fibroid, synechiae, polyp, hydrosalpinx;
• •Balanced translocations in both spouses;
• •Diabetes type I or II;
• •Sickle cell disease;
• •Contraindication to pregnancy;
• •Constitutional or acquired thrombophilia (protein deficit C, S, ATIII, homozygous factor V or II deficiency, antiphospholipid syndrome, antithyroid antibodies positive, celiac disease, hyperhomocysteinemia);
• •Ovarian insufficiency (AMH \<1 ng/ml); AFC \< 4
• •Significant spermogram abnormalities and DNA fragmented more than 30%
• •Active HIV or HCV infection;
• •Main known contraindications to treatment with IL-2:
• •Hypersensitivity to the active substance or to any of the excipients;
• •Signs of progressive infection requiring antibiotic therapy;
• •History of organ allograft;
• •Pre-existing autoimmune disease;
• •Leukocytes \<4000 / mm3; platelets \<100,000 / mm3; hematocrit \<30%;
• •hepatic or renal insufficiency;
• •depression;
• •significant history or existence of a serious heart disease (in doubtful cases, perform a stress test);
• •patients with autoimmune disease;
• •patients with an infection (septicemia, bacterial endocarditis, septic thrombophlebitis, peritonitis and pneumonia);
• •pregnancy;
• •Treatment with immunomodulators, immunosuppressants (class L04A of the ATC classification), in particular systemic corticosteroids, as well as aspirin and low molecular weight heparin;
• •No affiliation to a social security;
• •Person who has already been included in this study or in another at the same time;
• •Major incapacitated patient (tutorship / curatorship);
• •Patient with an allergy to taking IL2-fd;
• •Participants who would present professional risk factors (eg ionizing exposure);