Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis

Exclusion Criteria

• •Women that are pregnant, breastfeeding or trying to conceive.
• •Patients with chronic daily narcotic use and any chronic pain or frequently reoccurring pain condition, other than endometriosis, that is treated with opioids or requires analgesics for more than 7 days per month.
• •Patients with abnormal liver function tests (greater than 3x normal limit) in the past year or history of liver disease. Routine screening of liver function is not required.
• •Non-English speaking or inability to read and understand English secondary, in part, to the need to read and report daily results in English.
• •Undiagnosed vaginal bleeding
• •Patients with history of opioid, illicit drug or alcohol abuse
• •Patients currently taking thioridazine
• •Patients with a history of suicidality
• •Patients with current or history of unstable depression or other psychiatric disorder who, by PI judgement, are unstable or not well controlled
• •Known, suspected or history of cancer of the breast
• •Active deep vein thrombosis, pulmonary embolism or history of these conditions
• •Active or recent arterial thromboembolic disease (e.g., stroke, myocardial infarction)