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Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis | Clinical Trials | Clareo Health

ENROLLING_BY_INVITATION

Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis

NCT03970005•Ohio State University

Summary

The Ohio State University Early Psychosis Intervention Center is implementing a specialized clinical program to serve individuals who meet clinical high risk criteria for a psychosis. The purpose of this study is to evaluate the long-term outcomes among individuals participating in this clinical service.

Detailed Description

The Ohio State University Early Psychosis Intervention Center (OSU EPICENTER) is implementing a specialized clinical program to serve individuals ages 12-25 who meet clinical high risk criteria for a psychosis (CHR-P). The purpose of this project is to evaluate (i) correlates of baseline characteristics among clinic participants; (ii) outcomes among individuals participating in this clinical service; and (iii) predictors and mediators of longitudinal outcomes among individuals participating in this clinical service.

Eligibility

Age

12 - 25 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Male and female patients between ages 12-25
•Individuals meeting clinical high-risk criteria for psychosis as determined using the Structured Interview for Psychosis Risk. Inclusive of individuals meeting any of the three CHR syndromes assessed by the SIPS (i.e., attenuated psychotic symptoms; brief intermittent psychosis, and genetic risk and functional deterioration) and/or individuals at all four current status specifiers for the SIPS (i.e., progression, persistence, partial remission, and full remission) given evidence that future worsening of symptoms and/or progression to psychosis is possible for individuals in each current status specifier category.
•Subjects with no evidence of a pre-existing intellectual disability defined as a premorbid IQ \>70 as estimated using the Reading subtest of the Wide Range Achievement Test-4
•Fluent in English per self-report

Locations (1)

OSU Harding Hospital

Columbus, Ohio, United States

Key Dates

Start Date

April 19, 2019

Primary Completion Date

September 1, 2026

Completion Date

September 1, 2026

Last Updated

February 25, 2026

Enrollment

100

ESTIMATED participants

Conditions

Prodromal Schizophrenia

Interventions

Step-Based Care Model

BEHAVIORAL

Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk

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Prodromal Schizophrenia

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TERMINATEDPHASE3

"Multimodal Prevention of Psychosis - Investigating Efficacy of N-Acetylcysteine and Psychotherapy in CHR-Patients"

NCT03149107

Prodromal Schizophrenia

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COMPLETEDNA

Effects of Cognitive Remediation on Cognition in Young People at Clinical High Risk of Psychosis

NCT01619319

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 25, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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