Treosulfan-TMI Conditioning and Rapamycin GvHD Prophylaxis Before Allo-HSCT

Exclusion Criteria

• •A hematopoietic cell transplantation-specific comorbidity index \> 4
• •Active non-controlled infectious disease at the moment of inclusion
• •Active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
• •Impaired liver function (Bilirubin \> 2.0 x upper normal limit; Transaminases \> 3.0 x upper normal limit)
• •Impaired renal function (Creatinine-clearance \< 60 ml/min; Serum Creatinine \> 1.5 x upper normal limit).
• •Pleural effusion or ascites \> 1.0 L
• •Pregnancy or lactation
• •Known hypersensitivity to treosulfan and/or fludarabine and/or rapamycin
• •Non-co-operative behaviour or non-compliance
• •Psychiatric diseases or conditions that might impair the ability to give informed consent
• •Previous spinal cord radiotherapy with dose ≥ 45 Gy equivalent