PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel Translocator Protein (TSPO) Radioligand

Exclusion Criteria

• •1. Patients or subjects with an increased risk of neurodegenerative diseases will be excluded if they
• •* Have other major neurological or medical diseases that may cause progressive weakness or cognitive dysfunction, such as structural brain or spinal cord disease, metabolic diseases, paraneoplastic syndromes, infectious diseases, peripheral neuropathy or radiculopathy or other significant neurological abnormalities
• •* Have an unstable medical condition that, in the opinion of the investigators, makes participation unsafe (e.g., active infection or untreated malignancy)
• •* Require daytime ventilator support at the time of study entry
• •* Are unable to travel to NIH
• •* Have recent exposure to radiation related to research (e.g., PET from other research) that, when combined with this study, would be above the allowable limits
• •* Have inability to lie flat and/or lie still on camera bed for at least two hours, including claustrophobia, overweight greater than the maximum for the scanner, and uncontrollable behavioral symptoms, which will be screened by an interview with patient and/or caregiver during the screening visit
• •* Are pregnant or breastfeeding
• •* Are unable to have an MRI scan (e.g., pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, or shrapnel fragments, metal fragments in the eye)
• •* NIMH employees/staffs or NIH employees who are subordinates/relatives/co-workers of investigators
• •2. Healthy subjects will be excluded if they
• •* Have any history of medical illness or injury with the potential to affect study data interpretation or to be any medical contraindication to the procedures performed in the study, including active infection and untreated malignancy.
• •* Have clinically significant laboratory abnormalities based on test performed under screening protocol 01-M-0254 or 17-M-0181
• •* Have recent exposure to radiation related to research (e.g., PET from other research) that, when combined with this study, would be above the allowable limits
• •* Have inability to lie flat on camera bed for at least two hours, including claustrophobia and overweight greater than the maximum for the scanner
• •* Are pregnant or breastfeeding
• •* Are unable to have an MRI scan (e.g., pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, or shrapnel fragments, metal fragments in the eye)
• •* NIMH employees/staffs or NIH employees who are subordinates/relatives/co-workers of investigators