Have type 1 diabetes mellitus.

Have had chronic or acute pancreatitis any time prior to study entry.

Have proliferative diabetic retinopathy or diabetic maculopathy or nonproliferative diabetic retinopathy requiring acute treatment.

Have disorders associated with slowed emptying of the stomach, or have had any stomach surgeries for the purpose of weight loss.

Have an estimated glomerular filtration rate \<30 mL/minute/1.73 m².

Have had a heart attack, stroke, or hospitalization for congestive heart failure in the past 2 months.

Have a personal or family history of medullary thyroid carcinoma or personal history of multiple endocrine neoplasia syndrome type 2.

Have been taking weight loss drugs, including over-the-counter medications during the last 3 months.

A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone