Multicentre Medical-economic Study Evaluating the Efficacy of Adding ZOlédronique Acid to STERéotaxique Radiotherapy in the Treatment of Vertebral Metastases

Exclusion Criteria

• •Cancer with inoperable thoracic and/or lumbar vertebral metastasis;
• •Painful patient unable to maintain a lying position for 30 minutes despite analgesic treatment;
• •Patient who has received external irradiation from the proposed irradiation area \> 20 Gy ;
• •Signs of neurological compression;
• •Spinal cord compression or epidural damage requiring surgery before radiotherapy;
• •Clinically significant hypersensitivity to zoledronic acid, other bisphosphonates or any excipient;
• •History of osteonecrosis of the maxilla or bone exposure or delayed healing after dental surgery;
• •Previous (less than 2 years) or ongoing treatment with a bisphosphonate;
• •Creatinine clearance \< 30 ml/min;
• •Pregnant or breastfeeding woman;
• •Patient protected or under guardianship or incapable of giving consent;
• •Impossibility to submit to the medical follow-up of the trial for geographical, social or psychological reasons.