Study of Chemotherapy Combination With Autologous Cell Immunotherapy in the Advanced Lung Cancer

Exclusion Criteria

• •Subjects who meet any of the following criteria could not participate in this study:
• •1. Adenocarcinoma subjects with EGFR sensitive mutation or ALK translocation; molecular detection of EGFR-sensitive mutations or ALK translocations is not required in squamous carcinoma patients.
• •2. NSCLC that had received docetaxel treatment in the past.
• •3. Other malignant tumors needed treatment within five years.
• •4. Allogeneic tissue/organ transplantation.
• •5. Participating in research drug therapy within 4 weeks before the first administration of the trial.
• •6. Systemic glucocorticoid therapy or any other form of immunosuppressive therapy (except glucocorticoid preconditioned with docetaxel) is being administered within 3 days before the first administration of the experimental therapy.
• •7. Received anti-tumor monoclonal antibody (mAb), chemotherapy, targeted small molecule therapy or major surgery within 4 weeks before the first use of the drug; received chest radiotherapy greater than 30 Gy within 6 months before the first use of the drug; and received chest radiotherapy with 30 Gy or less within 1 month before the first use of the drug.
• •8. Previous treatment with PD-1/PD-L1 antibodies.
• •9. Over the past two years, patients with active autoimmune diseases requiring systemic treatment, such as the use of corticosteroids, or immunosuppressants. Substitution therapy (such as thyroxine, insulin, or physiological corticosteroid replacement therapy for adrenal or pituitary dysfunction) is not a systemic treatment.
• •10. Patients with congenital or acquired immunodeficiency (e.g. HIV-infected persons), active hepatitis B (HBV-DNA \> 10\^3 copies/ml) or hepatitis C (hepatitis C antibody positive), and HCV-RNA higher than the detection limit of the analytical method.
• •11. Subjects with active central nervous system (CNS) metastases and/or cancerous meningitis.
• •12. Patients with active infections requiring systemic intravenous therapy.
• •13. Mental illness or other illnesses, such as uncontrollable heart disease or pulmonary disease, diabetes, etc.
• •14. Subjects who are known to be allergic to any of the constituents of the drug being studied.
• •15. Subjects with a recent history of drug abuse (including alcohol) within one year.
• •16. Compliance is poor and can not cooperate with clinical research.
• •17. Female subjects who are pregnant or breastfeeding, or who are expected to be pregnant during the trial.