Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, Irvine
With
University of Minnesota
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
35–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Physician diagnosed type 2 diabetes ≥ 6 months prior to screening
HbA1c 6.5-8.5% at participant screening
Current treatment with lifestyle changes or stable diabetes-related medication levels for the past 3 months
Willingness to provide consent to contact treating physician and physician agreement to refrain from changing diabetes-related medications during the trial (change defined as \> 2 fold change in dose of any 1 hyperglycemic agent or addition or subtraction of an agent)
No physician-directed medication change for 3 months if prescribed medication for lipids or blood pressure
Usual consumers of diet beverages (≥ 3 servings/ week (24 oz.) and the willingness to maintain fidelity of the intervention, and participate in all aspects of the intervention
Not actively looking to make major lifestyle alterations during the study period with stable weight for 2 months (within 3%).
You may not be if
Type 1 diabetes or suspected type 1 diabetes (lean with polyuria, polydipsia, and weight loss with little response to metformin)
"Secondary" diabetes due to specific causes (e.g. monogenic syndromes, pancreatic surgery, and pancreatitis)
Diabetic Ketoacidosis hospitalization within last 6 months
Severe/major hypoglycemia in the last 3 months-severe/major hypoglycemia is defined as a hypoglycemic event in which patient requires assistance of another person to manage the episode
Glucocorticoid use (prednisone 2.5 mg/d or more or its equivalent)
History of intolerance or allergy to diet beverages or AS or phenylketonuria
Any condition that is known to affect the validity of the glycemic measures (Hba1c)
Major cardiovascular disease event or surgery within past 6 months
Gastrointestinal disease
Renal or liver disease
Current treatment for cancer
Those with major surgery planned or history of bariatric surgery
Antibiotic treatment (\> 6 days) within past 6 months
Currently pregnant (via self-report) or planning to become pregnant during study period; \<1 year postpartum and breast feeding
Current participation in another interventional clinical trial
Previous randomization in this study,
Heavy alcohol consumption (on average \>2 drinks/day for women and \>3 drinks/day for men)
Habitual consumer of SSB ≥ 1 serving / day (8 oz.)
