Longitudinal Innate Immunity and Aging Study

Exclusion Criteria

• •1. Major psychiatric disorder (e.g. schizophrenia, bipolar disorder, untreated major depression within past year)
• •2. Neurological conditions affecting cognition (e.g. Parkinson's disease, epilepsy (onset prior than 2 years ago), head trauma with loss of consciousness \>5 min within past two years, large vessel infarct, mild cognitive impairment, or dementia)
• •3. CNS immune conditions and other conditions affecting cognition (e.g., multiple sclerosis, paraneoplastic encephalitides; Hashimoto's encephalopathy; systematic lupus erythematosus)
• •4. Systematic illness (e.g.,current cancer, renal failure, respiratory failure)
• •5. Substance abuse/dependence (DSM-V criteria)
• •6. Current medication use likely to affect CNS (e.g., long-acting benzodiazepines, neuroleptics in the phenothiazine and haloperidol families)
• •7. Current medication use that precludes lumbar punctures (e.g. anticoagulants, antiplatelets, heparin shots, or some other blood thinner medications: Warfarin \[coumadin\], Pradaxa \[dabigatran\], Xarelto \[rivaroxaban\]. Eliquis \[apixaban\], or Plavix \[clopidogrel\].
• •8. Significant sensory or motor deficits that would interfere with cognitive testing
• •9. Factors that preclude MR imaging (e.g., pacemaker)
• •10. Factors that preclude lumbar puncture