Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity

Exclusion Criteria

• •Participant who is an employee of the investigational site, either directly involved in the conduct of the study or a member of their immediate family; or an employee of the investigational site otherwise supervised by the investigator; or a GlaxoSmithKline Consumer Healthcare (GSK CH) employee directly involved in the conduct of the study or a member of their immediate family
• •Participant who has participated in other studies (including non-medicinal studies) involving investigational product(s) within 30 days prior to study entry and/or during study participation
• •Participant with, in the opinion of the investigator or medically qualified designee, an acute or chronic medical, oral, psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator or medically qualified designee, would make the participant inappropriate for entry into this study
• •Participant with any condition which, in the opinion of the investigator or medically qualified designee, causes xerostomia
• •Participant who is a pregnant female (as evidenced by a positive Urine Pregnancy Test \[UPT\] at Screening)
• •Participant who is a breast-feeding female
• •Participant with known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients
• •Participant with a recent history (within the last year) of alcohol or other substance abuse
• •Participant who has participated in another tooth desensitizing treatment study within 8 weeks Screening
• •Participant who has used an oral care product indicated for the relief of DH within 8 weeks of Screening (participant will be required to bring their current oral care products to the site in order to verify the absence of known anti-sensitivity ingredients)
• •Participant who has had dental prophylaxis within 4 weeks of Screening
• •Participant who has had a tooth bleaching procedure within 8 weeks of Screening
• •Participant who has had treatment for periodontal disease (including surgery) within 12 months of Screening
• •Participant who has had scaling or root planning within 3 months of Screening
• •Participant with gross periodontal disease
• •Participant with evidence of gross intra-oral neglect or the need for extensive dental therapy
• •Participant with a tongue or lip piercing or presence of multiple dental implants
• •Participant with fixed or removable partial dentures
• •Participant with fixed or removable orthodontic braces/bands or a fixed orthodontic retainer
• •SPECIFIC DENTITION EXCLUSIONS FOR 'TEST TEETH':
• •1. Tooth with evidence of current or recent caries or reported treatment of decay within 12 months of Screening
• •2. Tooth with exposed dentin but with deep, defective or facial restorations
• •3. Tooth with full crown or veneer
• •4. Sensitive tooth with contributing etiologies other than erosion, abrasion or recession to exposed dentin
• •5. Sensitive tooth not expected to respond to treatment with an over-the-counter dentifrice in the opinion of the investigator
• •Participant taking daily doses of medication/treatments which, in the opinion of the investigator or medically qualified designee, could interfere with the perception of pain (examples of such medications include analgesics, anticonvulsants, antihistamines that cause marked or moderate sedation, sedatives, tranquilizers, antidepressants, mood-altering and anti-inflammatory drugs)
• •AT VISIT 1 (Screening):
• •Participant who has taken antibiotics in the 2 weeks prior to the Screening visit
• •\- AT VISIT 2 (Baseline): Participant who has taken antibiotics in the 2 weeks prior to the Baseline visit, during the acclimatization period
• •Participant taking daily doses of a medication which, in the opinion of the investigator or medically qualified designee, is causing xerostomia
• •Participant who requires antibiotic prophylaxis for dental procedures
• •Participant who has previously been enrolled in this study
• •Participant who, in the opinion of the investigator or medically qualified designee, should not participate in the study