SEEG Guided RF-TC v.s. ATL for mTLE With HS

Inclusion Criteria

• •Clinical diagnosis of drug resistant epilepsy
• •At least one or more anti-epileptic drugs (AEDs) regular administered for more than 2 years, one of which was either Dilantin, Tegretol, Carbatrol, or Trileptal used in appropriate doses, have failed due to inefficacy, not intolerance
• •Persistence of disabling seizures at least 3 times per 3 months or greater, and once or more in recent 1 month
• •14 years or older at enrollment
• •Simple and complex partial seizures, with or without secondarily generalized seizures beginning in childhood or later, with or without febrile convulsions earlier
• •Auras that occur in isolation and are not primary sensory other than olfactory or gustatory
• •I.Q. of greater than 70
• •Hippocampal atrophy on MRI T1 imaging with increased ipsilateral mesial signal on T2 imaging
• •Interictal EEG shows focal or lateralized spikes on temporal, frontal zone, or sphenoid electrode
• •Ictal EEG onset is focal or lateralized on the ipsilateral side
• •Ipsilateral temporal focal hypometabolism on PET
• •Must be agreed by a consensus of ipsilateral mesial temporal origin by a multidisciplinary discussion
• •Must be able to understand and speak Mandarin