Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX) in Participants With Locally Advanced, Unresectable Pancreatic Cancer

1. Prior chemotherapy or radiation for pancreatic cancer

2. Previous (within the past 3 years) or concurrent malignancy diagnosis except non-melanoma skin cancer and in situ carcinomas (excluding in situ breast cancer)

3. Major surgery within 4 weeks prior to signing informed consent form. Biliary stents are permitted.

4. History of allergy or hypersensitivity to human, humanized or chimeric monoclonal antibodies

5. History of allergy or hypersensitivity to any of the chemotherapy agents being prescribed or their excipients

6. Any medical or surgical condition that may place the participant at increased risk while on study

7. Any condition potentially decreasing compliance to study procedures

8. Exposure to another investigational drug within 28 days of first dosing visit, or 5 half-lives of the investigational drug (whichever is longer)

9. Uncontrolled intercurrent illness including, but not limited to, ongoing or active systemic infections, symptomatic congestive heart failure, unstable angina pectoris, clinically significant cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

10. Documented history of drug or alcohol abuse within 6 months of signing informed consent

11. Any medical condition that, in the opinion of the investigator, may pose a safety risk to a participant in this trial, may confound the assessment of safety and efficacy, or may interfere with study participation

12. Participants with a history of interstitial pulmonary disease, hepatitis C virus (HCV), hepatitis B virus (HBV) or human immunodeficiency virus (HIV) infection

13. Participants who have been administered a live vaccine within 4 weeks prior to the first administration of therapy

14. Participants who cannot stop chronic medications that inhibit or induce cytochrome P (CYP) 2C8 or CYP3A4

15. Participants with poorly controlled comorbid conditions, including; congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), uncontrolled diabetes mellitus (DM) or neurologic disorders (not acutely related to pancreatic cancer) or limited function

What this study is about