Clinical Research of ROBO1 Specific CAR-NK Cells on Patients With Solid Tumors

Inclusion Criteria

• •1. Age 18 \~ 75 years old, male or female
• •2. Life expectancy ≥ 6 months
• •3. ECOG score: 0 - 3
• •4. ROBO1 expression in malignancy tissues detected by immuno-histochemistry (IHC)
• •5. Advanced solid tumor was diagnosed by pathological or clinical physicians
• •6. Laboratory examination: white blood cell ≥ 3 x 10\*9/L, blood platelet count ≥ 60 x 10\*/L, hemoglobin ≥ 85g/L; lymphocyte count ≥ 15%, total bilirubin ≤ 100 mol/L; ALT and AST less than five times of the normal level; serum creatinine less than 1.5 times of the normal level
• •7. Signed informed consent
• •8. Women of child-bearing age must have evidence of negative pregnancy test and be willing to practice birth control after 2 weeks following the cell transfusion