Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Eli Lilly and Company
Age
18–85
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
All Participants:
Women of childbearing potential are excluded from the study.
Women not of childbearing potential may participate and include those who are infertile due to surgical sterilization (hysterectomy, bilateral oophorectomy, or tubal ligation), congenital anomaly such as mullerian agenesis; or postmenopausal
Are between the body mass index (BMI) of 19.0 and 40.0 kilograms per meter squared (kg/m²), inclusive, at screening
Healthy Participants:
\- Healthy males or females as determined by medical history, physical examination, and other screening procedures, with normal liver function
Participants with Impaired Liver Function:
Males or females with chronic mild, moderate and severe liver impairment, assessed by Child-Pugh scoring
Have type 2 diabetes mellitus (T2DM) controlled with diet or exercise alone or on stable doses of metformin for at least 8 weeks
Have a hemoglobin A1c (HbA1c) ≥6.0% and ≤11.0% at screening
You may not be if
All Participants:
Have known allergies to tirzepatide or related compounds
Have a personal or family history of medullary thyroid carcinoma or have multiple endocrine neoplasia syndrome type 2
Have a history or presence of pancreatitis (history of chronic pancreatitis or idiopathic acute pancreatitis), elevation in serum amylase or lipase or GI disorder (eg, relevant esophageal reflux or gall bladder disease) or any GI disease which impacts gastric emptying (eg, gastric bypass surgery, pyloric stenosis, with the exception of appendectomy) or could be aggravated by glucagon-like peptide-1 (GLP-1) analogs or dipeptidyl peptidase IV (DPP-IV) inhibitors
Participants with Impaired Liver Function:
Have hemoglobin \<8.5 grams per deciliter (g/dL)
Have kidney function that is significantly impaired at screening
Have taken any glucose-lowering medications other than metformin, including insulin, in the past 3 months before screening
Have brain function impaired significantly due to liver condition
