Multimodal Imaging Study on Physical Activity in Patients With Alzheimer's Disease

Exclusion Criteria

• •Heart attack or evidence of coronary heart disease (angina) in the last 2 years
• •Severe systemic disease, which is expected to worsen during exercise
• •Difficult to adjust diabetes mellitus II
• •Difficult to set art. Hypertension in the last 6 months
• •Severe psychiatric illness
• •Severe orthopedic disease
• •Alcohol and / or drug abuse in the last 2 years
• •Chronic pain and / or musculoskeletal disease, which prevent regular physical activity
• •Acute fracture or orthopedic injury last month
• •cancer in the last 5 years (except basal cell and spinal cell carcinoma) Contraindications for MRI examination below 3 Tesla (for example, implantation of ferromagnetic parts) For study participants, the following measures must be observed due to the direct effects of the magnetic field, in particular the force exerted on para- or ferromagnetic bodies: Study participants with incorporated metallic implants are not admitted. Pregnancy or lactation, traumatic brain injury, neurological or psychiatric disorders (other than the neurological disease to be studied for patients), relevant and severe other medical conditions, e.g. metabolic, endocrinological or cardiac disorders, mental retardation, magnetic metal implants (also intrauterine spiral).
• •Furthermore, the spatial conditions in the magnet do not allow to examine persons with certain back complaints or a strong overweight. As a rule, a body mass index (BMI, weight \[kg\] / size2 \[cm2\]) of \> 30 is the exclusion criterion. With regard to the participation in the exercise in advance with unclear suitability is a consultation with the attending family doctor regarding possible contraindications, which are a regular participation in a sports program in the way.
• •Diseases:
• •epilepsy
• •severe cardiac pre-existing conditions
• •Musculoskeletal disorders that are contrary to regular exercise
• •advanced osteoporosis
• •Increased fall risk / imbalance
• •Advanced Heart Failure, Shortness of Breath, Severe Pulmonary Disease, which are contrary to regular physical activity
• •Diabetes mellitus prone to hypoglycaemia and hyperglycemia
• •Conditions:
• •pregnancy
• •Uncertain knowledge about possibly existing pregnancy
• •Contraceptives:
• •Any type of intrauterine device
• •Spiral made of copper Metal-containing implants or devices in / on the body (all non-metal implants / devices / patches will undergo a thorough examination based on the MRI Safety
• •Listing www.mrisafety.com):
• •Pacemaker / implanted pacemaker wires
• •Implanted defibrillator
• •Drug pump / infusion device
• •Stimulation device / electrodes
• •Non-MRI-compatible implants, for example, surgical screws, plates, nails, etc:
• •vascular / lumen filters, wire rings, wire spirals, stents, vascular clips
• •Artificial heart valve
• •Transdermal patches
• •epithesis (or partial epithesis)
• •shunts, catheters, wire sutures
• •Metal in / on the body:
• •Splinter / gunshot wounds
• •Metal shards in the eye, even if everything was supposedly removed
• •Piercing
• •Dental metals:
• •Any type of implant in the jawbone area / dental implant older than 20 years
• •No contraindications: Amalgam fillings, inlays, crowns, single crowned teeth as a denture base for a denture termed a telescopic denture, firmly screwed dentures
• •Additional:
• •cochlear implant
• •Ventilation Tubes
• •tattoos / permanent make-up (only after the most exact examination and special approval see separate explanation)