Boiled Peanut Immunotherapy for the Treatment of Peanut Allergy

Exclusion Criteria

• •Required previous admission to an intensive care unit for management of an allergic reaction to peanut.
• •Clinically significant chronic illness (other than asthma, rhinitis or eczema).
• •Undergoing subcutaneous or sublingual immunotherapy to respiratory allergens, and not yet established on maintenance dosing for at least 3 months.
• •Undergoing oral immunotherapy for food allergy and within the first year of treatment.
• •Subjects receiving anti-IgE therapy, oral immunosuppressants, beta-blocker or ACE inhibitor.
• •Tolerance to ≥1.44 g peanut protein (approx. 6 peanuts) at initial DBPCFC during screening.
• •Dose-limiting symptoms to 1/8 boiled peanut (boiled for 4 hours) at screening.
• •Poorly controlled asthma within the previous 3 months (as defined by clinician judgement with reference to the ICON consensus ), or asthma requiring treatment with \>5 days oral corticosteroids within the previous 3 months.
• •Pregnancy
• •Unwilling or unable to fulfil study requirements