Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD

Exclusion Criteria

• •current enrollment in an acute experimental treatment for PTSD or trauma-focused psychotherapy treatment
• •PTSD-inducing trauma exposure occurring within the last 3 months prior to pre-enrollment evaluation
• •history of epilepsy or seizure disorder, a history of major head trauma,
• •any neurologic condition likely to increase risk of seizures,
• •brain tumors,
• •moderate to severe substance use disorder in last 3 months or any substance use that puts the participant at increased risk or significant impairment
• •stroke, and blood vessel abnormalities in the brain,
• •dementia,
• •Parkinson's disease, Huntington's chorea, or multiple sclerosis
• •a high suicide risk
• •a lifetime history of psychotic disorder or bipolar disorder
• •inability to stop taking any medication that significantly lowers the seizure threshold
• •pregnant or nursing
• •metal fragments in the head, or any metal objects in or near the head that cannot be safely removed
• •We will screen for a history of traumatic brain injury and exclude potential participants from the study if they have a history of severe TBI or are at high risk for seizures.
• •history of seizures
• •non-English speakers because not all of the screening forms, questionnaires, and tests are available in any language except for English
• •cardiac pacemaker, implanted medication pumps of any sort that would increase the risk of rTMS
• •any current medical condition that could preclude being able to safely participate in TMS treatment,
• •use of prescription medication or illegal substances that lower the seizure threshold
• •previous rTMS