Lead Sponsor

University of California, Berkeley

Collaborators

Age

50 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•Healthy Volunteers: Subjects must be aged 50 and over. These individuals will all be of good general medical health with no neurological diseases and capable of providing informed consent.
•Patients: Subjects must be aged 50 and over. Patients will meet diagnostic criteria at UCSF for Alzheimer's disease (AD), mild cognitive impairment (MCI), or progressive supranuclear palsy (PSP).

•Any medical contraindications to an MRI scan
•A pacemaker
•Metal clips in brain or tattoos above neck
•Metallic implants or shrapnel in body
•Any body jewelry or piercings that are not removable
•A history of claustrophobia
•A known major systemic disease
•A history of a psychiatric disorder
•A history of substance abuse (prescription or non-prescription) within the past 5 years
•A current weight of less than 45 kilograms (100 pounds)
•Difficulty in urinating or emptying the bladder
•Under age 50
•Participating in an experimental radiotracer study
•Subjects must be fluent English speakers