This will be a 3-arm, multicentered, randomized, double-masked, vehicle-controlled study conducted in 2 parts.
Part 1 is the primary treatment period of 3 years, during which participants will receive 1 of 3 masked medications.
Part 2 is the randomized withdrawal period of 1 year, during which participants originally receiving Vehicle will receive SYD-101, and participants originally receiving SYD-101 will receive either Vehicle or SYD-101.