Finding studies
Finding studies
Take this into the appointment.
Saves the questions and what to expect into your notes, next to the visit they belong to.
Lead
UNC Lineberger Comprehensive Cancer Center
Lymphodepleting Chemotherapy: The patient will receive a lymphodepleting regimen of bendamustine 70mg/m2/day over 3 consecutive days and fludarabine 30mg/m2/day over 2 consecutive days. Bendamustine and fludarabine will be administered concomitantly. Dose reduction of bendamustine may occur per treating physician discretion based on prior toxicities and the clinical status of the patient. Administration of ATLCAR.CD30 T cells: Post lymphodepletion, if the patient meets eligibility criteria for cellular therapy, then will receive ATLCAR.CD30 T cells within 2-14 days after completing the pre-conditioning chemotherapy regimen. We will administer ATLCAR.CD30 T cells post lymphodepletion at a dose of 2 x 10\^8 cells/m2. Duration of Therapy: Therapy under this compassionate use protocol involves 1 infusion of ATLCAR.CD30 cells. Duration of Follow-up: The patient will be followed for up to 15 years for replication-competent retrovirus evaluation or until death, whichever occurs first.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
