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UC-MSC Transplantation for Left Ventricular Dysfunction After AMI | Clinical Trials | Clareo Health

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UC-MSC Transplantation for Left Ventricular Dysfunction After AMI

Safety and Efficacy Evaluation of Umbilical Cord Mesenchymal Stem Cells Transcatheter Transplantation to Treat Left Ventricular Dysfunction After Acute Myocardial Infarction

NCT03902067•Shanghai Life Science & Technology

View on ClinicalTrials.gov

Summary

A pilot study to evaluate the safety and feasibility of umbilical cord mesenchymal stem cells in the treatment of acute myocardial infarction by catheter transplantation

Detailed Description

In this study, 40 patients with cardiac insufficiency after acute myocardial infarction were selected and randomly divided into umbilical cord MSCs transplantation treatment group and non-intervention control group to preliminarily observe the safety and effectiveness of MSCs cell transplantation treatment.

Eligibility

Age

50 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients with acute extensive anterior myocardial infarction were successfully treated with emergency interventional therapy within 12 hours after onset. LVEF was less than 0.35 by echocardiography 30 days after operation, scar area was more than 25% by MRI, and cardiac function was NYHA III-IV grade.
•Fully inform the purpose, method and possible side effects of the test, agree to the test, and sign an informed consent form;
•Good compliance, willing to take drugs and follow up according to the requirements of the plan;
•Life expectancy exceeds one year.

Exclusion Criteria

•Those who cannot tolerate cell therapy;
•Patients with severe hepatic and renal insufficiency (ALT\>1.5 times the upper limit of normal value, Cr \>1.5 times the upper limit of normal value);
•Patients with malignant tumors or extremely weak patients;
•Patients with severe infection;
•Patients who are expected to have the second coronary intervention or bypass grafting within 3 months;
•Patients with other serious systemic diseases and organ dysfunction;
•Patients with cardiogenic shock;
•Patients with hemorrhagic diseases;
•Researchers believe that anyone who is not suitable for inclusion

Locations (1)

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Shanghai, Shanghai Municipality, China

Key Dates

Start Date

December 1, 2024

Primary Completion Date

December 31, 2025

Completion Date

December 31, 2025

Last Updated

April 25, 2024

Enrollment

ESTIMATED participants

Conditions

Left Ventricular DysfunctionAcute Myocardial Infarction

Interventions

UC-MSC

BIOLOGICAL

Control Group

BIOLOGICAL

Contacts

Chengxing Shen

CONTACT

+86-18501664545 shencx@sjtu.edu.cn

Gang LU

CONTACT

+862134712825 glu@shlifestemcell.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 25, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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UC-MSC Transplantation for Left Ventricular Dysfunction After AMI

Inclusion Criteria

Exclusion Criteria

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