Effect of Lifestyle and/or Metformin Intervention on Pregnancy Outcome, A Pilot Randomized Controlled Trial

Exclusion Criteria

• •1. Women with endometriosis.
• •2. Women with untreated hydrosalpinx.
• •3. Women with a uterine cavity abnormality, such as a uterine congenital malformation; untreated uterine septum(except shallow uterine septum), adenomyosis, submucous myoma, or intrauterine adhesions.
• •4. Women who are indicated and planned to undergo preimplantation genetic diagnosis(PGD)/preimplantation genetic screening(PGS).
• •5. Women with endocrine abnormalities, such as Cushing syndrome, congenital adrenal hyperplasia, pituitary amenorrhea, thyroid dysfunction etc.
• •6. Women who had participated in other treatments known to affect diet or weight (such as diet drugs and dietitian intervention) for past 3 months.
• •7. Women who are unable to follow verbal and written instructions.
• •8. Women who use donated oocytes to achieve pregnancy.
• •9. Women with poor ovarian response(Bologna criteria).
• •10. Women with diabetes mellitus, abnormal glycosylated hemoglobin.
• •11. Women who has a history of recurrent spontaneous abortion.