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A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers | Clinical Trials | Clareo Health

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COMPLETEDPhase 1NCT03892499

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

To evaluate the effect of itraconazole (a potent cytochrome P450 isoenzyme \[CYP\]3A inhibitor) on the pharmacokinetics (PK) of olinciguat

Lead sponsor: Cyclerion Therapeutics•1 U.S. locations•View source on ClinicalTrials.gov

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: July 15, 2019Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE1

Enrollment24

Start dateMay 2019

Last updatedJul 15, 2019

Condition

Healthy

Locations shown

PPD

Austin, Texas

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 15, 2019Data synced to Clareo: May 3, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

What this study is about

Clareo turns complex medical information into clear understanding you can use.

Sponsors

Related studies

Cytapheresis of Volunteer Donors

A Study to Compare the Amount of Two Forms of Tafamidis in the Blood of Healthy Adults Under Fed Conditions

A First-in-human Study of the Safety of an Immunosuppressive Antibody (IMP761) in Healthy Volunteers

Sodium vs Potassium Education to Improve Vascular Health

A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)

Trial snapshot

Condition

Locations shown

For caregivers