Diagnosis of large duct PSC

Liver biopsy at screening that is deemed acceptable for interpretation and demonstrates stage F0 - F3 fibrosis in the opinion of the central reader

Individual has the following laboratory parameters at the screening visit, as determined by the central laboratory:

* Platelet count ≥ 150,000/mm\^3

* Estimated glomerular filtration rate (eGFR) ≥ 30 milliliter/minute (mL/min), as calculated by the Cockcroft-Gault equation

* Alanine transaminase (ALT) ≤ 8 x upper limit of the normal range (ULN)

* Total bilirubin \< 2 mg/dL, unless the individual is known to have Gilbert's syndrome or hemolytic anemia

* International normalized ratio (INR) ≤ 1.4, unless due to therapeutic anticoagulation

* Negative anti-mitochondrial antibody

Study of Cilofexor in Adults With Primary Sclerosing Cholangitis