Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products

This is a prospective PK/PD study that will include patients who are currently legally consuming one of the four medical marijuana formulations (Dream, Soothe, Shine and Ease) from Ilera Healthcare as part of their standard therapy for one of the state approved serious medical conditions. Part 1 of the study consists of intake data of select subjects. * The patients will be identified at a dispensary that offers Ilera products. * Patients be given a flyer about the study by either study staff or dispensary staff. * Eligible patients will be asked to contact the study team if they are interested in the study. * If the patient is interested, a face-to-face (in person at the dispensary or in the patients home or other agreed upon location) consent/assent will be obtained. * Also, since it is possible that Investigators will enroll subjects across the region, Investigators anticipate the need to seek consent over the phone for many patients. This will be done via Skype, Go to Meeting, Facetime or similar platforms so that the investigators can have a face to face interaction with the potential subjects. Investigators will obtain written consent in all cases. Investigators will have them sign and fax or email/scan the signed consent form back to the study team. * Once consent is obtained demographic information will be collected as well as a medical and medication history and several questions related specifically to the medical marijuana product and its perceived effectiveness. * The data will be recorded in the REDCAP database. Part 2 of the study consists of pharmacokinetic evaluation of select subjects. * Parents/ care providers/ patients when appropriate will undergo education regarding PK sample acquisition * PK blood samples will be obtained and sent to the Children's Hospital of Philadelphia (CHOP) for determination of cannibidiol/ Tetrahydrocannabinol/ cannabinol (CBD/THC/CBN) concentrations * PK and PD analysis will occur