Effect of REST in the Alzheimer Disease Continuum

Exclusion Criteria

• •1. Meet the DSM-IV diagnostic criteria of dementia;
• •2. Obvious cerebrovascular diseases in MRI;
• •3. Depression or other mental illnesses that meet the DSM-IV criteria in the past 2 years, the simplified version of the Geriatric Depression Scale (GDS-15) ≥ 8 ;
• •4. A history of alcohol or substance abuse or addiction in the past 2 years;
• •5. History of schizophrenia;
• •6. Any obvious neurological diseases, such as Parkinson's disease, Huntington's disease, normal pressure hydrocephalus, brain tumors, progressive supra nuclear paralysis, epilepsy, chronic subdural hematoma, multiple sclerosis, severe head trauma with persistent neurological impairment or known structural brain abnormalities;
• •7. In investigator's impression, the subject cannot cooperate with the research procedure;
• •8. Other known systemic diseases that cause dementia (such as hypothyroidism, folate or vitamin B deficiency, neurosyphilis, HIV infection).
• •1. With severe cerebrovascular disease, defined as a history of stroke temporal associated with the occurrence or deterioration of cognitive impairment; Or the occurrence of multiple or severe infarction or severe white matter high signal;
• •2. Have the core characteristics of Lewy body dementia rather than dementia itself;
• •3. Significant characteristics of frontotemporal dementia with behavioral variation;
• •4. Significant characteristics of primary progressive semantic aphasia or primary progressive non-fluency/grammatical confusion aphasia;
• •5. Evidence of other complications of active neurological diseases, or non-neurological complications, or serious cognitive effects of drug use;
• •6. Depression or other mental illnesses that meet the DSM-IV criteria in the past 2 years, the simplified version of the Geriatric Depression Scale (GDS-15) ≥ 8 points;
• •7. Other known systemic diseases that cause dementia (such as hypothyroidism, folate or vitamin B deficiency, neurosyphilis, HIV infection).