Iodine-125 Seed Implantation Therapy for Locally Advanced Pancreatic Cancer

Inclusion Criteria

• •Age: 18-80 years
• •Cytologically or histologically confirmed pancreatic adenocarcinoma
• •Inoperable locally advanced pancreatic cancer based on American Joint Committee on Cancer (AJCC) staging system (8th ed) (without distant metastasis)
• •Single tumor size≤ 6 cm
• •Karnofsky performance score （KPS）≥60
• •Estimated survival ≥3 months
• •Without other several comorbidity
• •Participants must have adequate organ function:
• •* WBC≥3×109/L; HGB≥90g/dL; PLT≥50×109/L
• •* Aspartate Transaminase (AST)/alanine aminotransferase ( ALT) ≤3 × institutional upper limit of normal
• •* Albumin≥3g/dL
• •* Total bilirubin ≤3mg/dL
• •* PT≤3 × institutional upper limit of normal or INR≤2.3
• •* Creatinine ≤1.5 × institutional upper limit of normal
• •Ability to understand and the willingness to sign a written informed consent document